The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans In the past decade, intense investigation has yielded considerable knowledge of1941, two more antigens were added to the Rh system C, described by Weiner,5 and c, described by Levine6 In 1943, the E antigen was described7,8 and added to the Rh system The e antigen was added in Today the Rh system is a complex group of 54 different specificities of red blood cell antigens (Table 1)10 ABO / Rh(D) Antigen TypeSeveral nomenclatures have been used to describe antigens, proteins, and genes in the Rh system Throughout this review, we will use traditional terminology recommended by the International Society of Blood Transfusion (ISBT) committee for terminology of blood group antigens5 The numeric portion of the ISBT terminology for Rh antigens is based on the nomenclature described Rh Blood Group System Wikipedia What is blood type and rh